Cyclooxygenase-2 Regulation in Colon Cancer Cells
نویسندگان
چکیده
منابع مشابه
Cyclooxygenase-2 and Colon Cancer
Cyclooxygenases (COX) also known as prostaglandin (PG) synthases are found in two forms, COX-1 and COX-2. While COX-1 is responsible for cytoprotective functions in a number of organs, COX-2, which is normally absent at basal levels, is induced under certain conditions. Induction of COX-2 is found in many pathophysiological states including acute inflammation, arthritis, as well as in cancer an...
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Both the sulfide and sulfone metabolites of sulindac, a nonsteroidal anti-inflammatory drug, display anticarcinogenic effects in experimental models. Sulindac sulfide inhibits cyclooxygenase (COX) enzyme activities and has been reported to suppress ras-dependent signaling. However, the mechanisms by which sulindac sulfone suppresses cancer growth are not as defined. We studied the effects of th...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.m411978200